Is there any connection between choroidal thickness and obesity?
Farshad AskarizadehMohsen HeiraniMasoud Khorrami-NejadForoozan Narooie-NooriMehdi KhabazkhoobAlireza OstadrahimiPublished in: Therapeutic advances in ophthalmology (2022)
Obesity is a health-threatening and epidemic medical condition that can affect individuals of different ages and is potentially associated with an increased risk of systemic and ocular disorders. Despite the well-documented adverse effects of obesity on different parts of the body vasculature, less published data are available concerning obesity-related consequences on the ocular vasculature. As the human choroid is a highly vascularized tissue, its morphology and function might be altered in obese individuals. The micro-structural changes within the choroid could also trigger development of subsequent functional abnormalities of the eye. Previous population-based studies have asserted an association between obesity and choroidal thickness; however, they reported conflicting patterns of association between obesity and changes in choroidal thickness. Therefore, to enhance our understanding of the changes in choroidal morphology secondary to obesity, we reviewed studies describing the micro-structural consequences of obesity on the choroidal thickness profile and its underlying physiological and anatomical basis. This review includes all original publications related to the association between choroidal thickness and obesity published until mid-2021 that were indexed in PubMed, Google Scholar, ScienceDirect, or Scopus.
Keyphrases
- optical coherence tomography
- weight loss
- metabolic syndrome
- insulin resistance
- type diabetes
- high fat diet induced
- weight gain
- bariatric surgery
- healthcare
- adipose tissue
- endothelial cells
- public health
- systematic review
- age related macular degeneration
- randomized controlled trial
- body mass index
- social media
- artificial intelligence
- risk assessment
- climate change
- machine learning
- deep learning
- adverse drug
- obese patients
- case control