The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.

Thomas Stephanus Johannes VaessenLea de JongAnnika Theresia SchäferThomas DamenAniek UittenboogaardPauline KrolinskiChinyere Vicky NwosuFlorentina Maria Egidius PinckaersIris Leah Marije RoteeAntonius Petrus Wilhelmus SmeetsAyşegül ErmişJames L KennedyDorien H NiemanArun TiwariJim van OsMarjan Drukker

Published in: PloS one (2018)

The interaction term between cannabis use and COMTVal158Met was only statistically significant in the case-only studies, but not in studies using other clinical or non-clinical psychosis outcomes. Future additional high quality studies might change current perspectives, yet currently evidence for the interaction remains unconvincing.

Keyphrases

case control
systematic review
tyrosine kinase
preterm infants
meta analyses
randomized controlled trial
copy number
gene expression
metabolic syndrome
dna methylation
glycemic control
preterm birth