Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis.

Zhendong ZhangQianwei ZhaoZexuan WangFang XuYixian LiuYaoyu GuoChenglong LiTing LiuYing ZhaoXiaolei TangJintao Zhang

Published in: Hepatology communications (2024)

Because ROS plays essential roles in many biological processes, such as aging and cancers, our findings suggest that NDFUB3 can be targeted for treating HCC and other human diseases.

Keyphrases

reactive oxygen species
endothelial cells
induced pluripotent stem cells
dna damage
cell death
cancer therapy
pluripotent stem cells
drug delivery
protein kinase
oxidative stress