A hidden proteome encoded by circRNAs in human placentas: Implications for uncovering preeclampsia pathogenesis.

Huanqiang ZhaoYu XiongZixiang ZhouQixin XuYang ZiXiujie ZhengShiguo ChenXirong XiaoLili GongHuangfang XuLidong LiuHuiqing LuYutong CuiShuyi ShaoJin ZhangJing MaQiongjie ZhouDuan MaXiaotian Li

Published in: Clinical and translational medicine (2024)

We discovered a hidden circRNA-encoded proteome in the human placenta, which offers new insights into the mechanisms underlying placental development, as well as placental disorders such as preeclampsia. Key points A hidden circRNA-encoded proteome in the human placenta was extensively identified and systematically characterised. The circRNA-encoded proteins (CEPs) are potentially related to placental development and associated disorders. A novel conserved CEP circPRKCB119aa enhanced trophoblast autophagy by inhibiting phosphorylation of its cognate linear-spliced isoform protein kinase C (PKC) β in preeclampsia.

Keyphrases

endothelial cells
protein kinase
early onset
induced pluripotent stem cells
pluripotent stem cells
signaling pathway
oxidative stress
transcription factor
pregnant women
pregnancy outcomes
heat shock
heat shock protein