Pharmacokinetics, Safety, and Tolerability of Once-Daily Darunavir With Cobicistat and Weekly Isoniazid/Rifapentine.

Kristina M BrooksAlice K PauDoris SwaimHaden T BunnLilian AdeojoCharles A PeloquinParag KumarJoseph A KovacsJomy M George

Published in: Journal of acquired immune deficiency syndromes (1999) (2023)

Darunavir exposures were significantly decreased with HP coadministration. Temporal relationships between HP coadministration and the extent of induction or mixed inhibition/induction of darunavir metabolism were apparent. Coadministration of darunavir/cobicistat with 3HP should be avoided.

Keyphrases

hiv infected patients
antiretroviral therapy
mycobacterium tuberculosis
physical activity
air pollution
open label
randomized controlled trial
clinical trial
computed tomography
study protocol