The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma.
Zhao ChengHasan B MirzaDarren P EnnisPhilip S SmithLena Morrill GavarróChishimba SokotaGaia GiannoneTheodora GoranovaThomas BradleyAnna PiskorzMichelle Lockleynull nullBaljeet KaurNaveena SinghLaura A TookmanJonathan KrellJacqueline McDermottGeoffrey MacintyreFlorian MarkowetzJames D BrentonIain A McNeishPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Early-stage and late-stage HGSCs have highly similar patterns of mutation and focal SCNA. However, CN signature analysis showed that late-stage disease has distinct signature exposures consistent with whole-genome duplication. Further analyses will be required to ascertain whether these differences reflect genuine biological differences between early-stage and late-stage or simply time-related markers of evolutionary fitness. See related commentary by Yang et al., p. 2730.