Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.
Michael D WeissEric A MacklinCourtney E McIlduffSteve VucicBrian J WaingerMatthew C KiernanStephen A GoutmanNamita A GoyalSeward B RutkoveShafeeq S LadhaI-Hweii Amy ChenMatthew B HarmsThomas H BrannaganDavid LacomisSasha ZivkovicMaxwell MaLeo H WangZachary SimmonsMichael H RivnerJeremy M ShefnerMerit E CudkowiczNazem Atassinull nullPublished in: Muscle & nerve (2020)
The relative stabilization of RMT in the treated subjects was unexpected and could be attributed to unaccounted sources of error or chance. However, a possible alternative cause is neuromodulation preventing an increase. The change in MEP amplitude and accommodation half-time supports the reduction of cortical and axonal hyperexcitability with mexiletine.