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Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.

Wenshuai LiuHanxing TongChenlu ZhangRongyuan ZhuangHe GuoChentao LvHua YangQiaowei LinXi GuoZhiming WangYan WangFeng ShenShengzhou WangChun DaiGuan WangJun LiuWeiqi LuYong ZhangYu-Hong Zhou
Published in: BMC cancer (2020)
Our analysis revealed different recurrent genetic variations in LMS and DDLPS including simultaneous upregulation of gene expression and gene copy number amplification of MDM2 and CDK4. Up-regulation of tumor related genes is favored in DDLPS, while loss of suppressor function is favored in LMS. DDLPS harbors more frequent fusion events which can generate neoepitopes and potentially targeted by personalized immune treatment.
Keyphrases
  • copy number
  • mitochondrial dna
  • gene expression
  • genome wide
  • dna methylation
  • single cell
  • cell proliferation
  • cell cycle
  • poor prognosis
  • cancer therapy
  • signaling pathway
  • nucleic acid
  • data analysis