Macrophages contribute to TKI resistance and enhance the migration of EGFR-mutated NSCLC cells through mechanisms involving TonEBP/NFAT5. Therefore, targeting TonEBP/NFAT5 represents a potential therapeutic strategy for overcoming macrophage-induced TKI resistance in NSCLC cells.
Keyphrases
- small cell lung cancer
- induced apoptosis
- advanced non small cell lung cancer
- tyrosine kinase
- epidermal growth factor receptor
- cell cycle arrest
- high glucose
- diabetic rats
- nuclear factor
- poor prognosis
- adipose tissue
- drug induced
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- endothelial cells
- immune response
- brain metastases
- cancer therapy