Downregulation of PLK4 expression induces apoptosis and G0/G1-phase cell cycle arrest in keloid fibroblasts.

Ru-Lin HuangChuanqi LiuRao FuYuxin YanJing YangXinggang WangQingfeng Li

Published in: Cell proliferation (2022)

These findings demonstrate that PLK4 is a critical regulator of KF proliferation, migration, and invasion, and thus, Cen-B is a promising candidate drug for keloid treatment.

Keyphrases

cell cycle arrest
signaling pathway
cell death
pi k akt
poor prognosis
cell proliferation
transcription factor
extracellular matrix
emergency department
long non coding rna
combination therapy