Adverse impact of bone metastases on clinical outcomes of patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors.

Xing LiLei WangShanhao ChenCaicun ZhouJing ZhaoWencheng ZhaoChunxia Su

Published in: Thoracic cancer (2020)

BoM attenuated the efficacy of ICI monotherapy in patients with advanced NSCLC. Of BoM+ patients who received ICI monotherapy, neither palliative radiotherapy nor bisphosphonate drugs improved OS. Other therapeutic strategies are needed for patients with BoM.

Keyphrases

advanced non small cell lung cancer
combination therapy
epidermal growth factor receptor
open label
early stage
palliative care
locally advanced
radiation induced
small cell lung cancer
randomized controlled trial
emergency department
clinical trial
squamous cell carcinoma
adverse drug
rectal cancer