LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice.
Devadoss J SamuvelYasodha KrishnasamyLi LiJohn J LemastersC James ChouZhi ZhongPublished in: RPS pharmacy and pharmacology reports (2023)
This novel HDACi protects against IRI most likely by epigenetic upregulation of antioxidant proteins and post-translational modifications of NFκB thus inhibiting iNOS expression and inflammatory responses.
Keyphrases
- histone deacetylase
- oxidative stress
- poor prognosis
- signaling pathway
- induced apoptosis
- long non coding rna
- diabetic rats
- ischemia reperfusion injury
- dna damage
- pi k akt
- dna methylation
- cerebral ischemia
- acute myocardial infarction
- high fat diet induced
- gene expression
- cell proliferation
- acute ischemic stroke
- binding protein
- heart failure
- nuclear factor
- nitric oxide synthase
- toll like receptor
- blood brain barrier
- insulin resistance
- immune response
- nitric oxide
- brain injury
- metabolic syndrome
- skeletal muscle
- left ventricular
- heat stress