L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation.

Beatriz Castejón-VegaAlejandro RubioAntonio J Pérez-PulidoJosé Luis QuilesJon D LaneBeatriz Fernández-DomínguezMaría Begoña Cachón-GonzálezCarmen Martín-RuizAlberto SanzTimothy M CoxElísabet Alcocer-GómezMario D Cordero

Published in: Cells (2021)

We contend that the expression of autophagy/lysosome/mTOR-associated molecules may prove useful peripheral biomarkers for facile monitoring of treatment of GM2 gangliosidosis and neurodegenerative disorders that affect the lysosomal function and disrupt autophagy.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell proliferation
poor prognosis
nitric oxide
quantum dots
binding protein
long non coding rna