Targeting skeletal muscle mitochondrial health in obesity.
Chantal A PileggiBreana G HooksRuth McPhersonRobert R M DentMary-Ellen HarperPublished in: Clinical science (London, England : 1979) (2022)
Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are altered in obesity, with some changes proceeding and some following the development of the disease. Nonetheless, there are marked interindividual differences in skeletal muscle composition and metabolism in obesity, some of which have been associated with obesity risk and weight loss capacity. In this review, we discuss related molecular mechanisms and how current and novel treatment strategies may enhance weight loss capacity, particularly in diet-resistant obesity.
Keyphrases
- weight loss
- skeletal muscle
- insulin resistance
- bariatric surgery
- roux en y gastric bypass
- metabolic syndrome
- high fat diet induced
- weight gain
- gastric bypass
- type diabetes
- adipose tissue
- oxidative stress
- glycemic control
- healthcare
- obese patients
- public health
- fatty acid
- blood pressure
- physical activity
- cancer therapy
- social media
- risk assessment
- climate change