Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease.

Astrid Elisabeth Mork-Jansson Ingvild Dalen Ole-Bjørn Tysnes Angus D Macleod Lars Forsgren Carl E Counsell Guido Werner Alves

Published in: Neurology (2020)

GBA variants are linked to a more aggressive motor disease course over 7 years from diagnosis in patients with PD. A better understanding of PD progression in genetic subpopulations may improve disease management and has direct implications for improving the design of clinical trials.

Keyphrases

parkinson disease
newly diagnosed
clinical trial
deep brain stimulation
copy number
randomized controlled trial
gene expression
open label
study protocol