Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients.
Nuha Mohamed GaafarTarig Al-Hadi OsmanIsraa Abdulrahman AhmedMariam ElsheikhHarsh DongreMartha Rolland JacobsenNazar Gafar MohamedSiren FromreideAhmed Mohamed SuleimanAnne Christine JohannessenElisabeth Sivy NginamauDaniela Elena CosteaPublished in: Clinical and experimental dental research (2021)
Despite heavy immune cell infiltration in tumor-associated stroma, the majority of OSCCs in this cohort displayed a low intraepithelial immune infiltration. An immunoscore based on combined CD4 and FoxP3 intraepithelial expression may serve as an indicator of advanced tumor progression and should be further investigated for its use as potential prognostic biomarker in OSCC.
Keyphrases
- high grade
- poor prognosis
- squamous cell
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- regulatory t cells
- prognostic factors
- long non coding rna
- risk assessment
- immune response
- patient reported outcomes
- high resolution
- mass spectrometry
- dendritic cells
- atomic force microscopy
- patient reported