FBXW24 controls female meiotic prophase progression by regulating SYCP3 ubiquitination.
Yang WangWen-Yi GaoLi-Li WangRuo-Lei WangZhi-Xia YangFu-Qiang LuoYu-Hao HeZi-Bin WangFu-Qiang WangQing-Yuan SunJing LiDong ZhangPublished in: Clinical and translational medicine (2022)
We proposed that FBXW24 regulates the timely degradation of SYCP3 to ensure normal crossover and DSB repair during pachytene. FBXW24-KO delayed SYCP3 degradation and DSB repair from pachytene until metaphase II (MII), ultimately causing failure in oocyte maturation, oocyte death, and infertility.