Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.
Cecilia EngdahlAlbert BondtUlrike HarreJasmin RauferRené PfeifleAlessandro CamponeschiManfred WuhrerMichaela SeelingInga-Lill MårtenssonFalk NimmerjahnGerhard KrönkeHans U SchererHelena Forsblad-d'EliaGeorg SchettPublished in: Arthritis research & therapy (2018)
E2 induces anti-inflammatory effector functions in IgG by inducing St6Gal1 expression in antibody-producing cells and by increasing Fc sialylation. These observations provide a mechanistic explanation for the increased risk of RA in conditions with low estrogen levels such as menopause.
Keyphrases
- postmenopausal women
- rheumatoid arthritis
- poor prognosis
- bone mineral density
- anti inflammatory
- induced apoptosis
- estrogen receptor
- disease activity
- binding protein
- ankylosing spondylitis
- long non coding rna
- type diabetes
- interstitial lung disease
- regulatory t cells
- oxidative stress
- metabolic syndrome
- dendritic cells
- high fat diet induced
- endoplasmic reticulum stress
- systemic lupus erythematosus
- cell death