Adiponectin improves long-term potentiation in the 5XFAD mouse brain.
Ming WangJihoon JoJuhyun SongPublished in: Scientific reports (2019)
Adiponectin is an adipokine that regulates apoptosis, glucose and lipid metabolism, and insulin sensitivity in metabolic diseases. As recent studies have associated changes in adipokines and other metabolites in the central nervous system with a risk for Alzheimer's disease (AD), we investigated the effects of adiponectin treatment on hippocampal cells in the 5XFAD mouse model of AD and neuronal SH-SY5Y cells under amyloid beta toxicity. Adiponectin treatment reduced levels of cleaved caspase 3 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) apoptosis signalling and decreased glycogen synthase kinase 3 beta (GSK3β) activation. Moreover, adiponectin treatment triggered long-term potentiation in the hippocampi of 5XFAD mice, which was associated with reduced expression of N-methyl-D-aspartate and its receptor as well as surface expression of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor. These findings suggest that adiponectin inhibits neuronal apoptosis and inflammatory mechanisms and promotes hippocampal long-term potentiation. Thus, adiponectin exhibits beneficial effect on hippocampal synaptic plasticity in Alzheimer's disease mouse model.
Keyphrases
- cell cycle arrest
- nuclear factor
- metabolic syndrome
- induced apoptosis
- oxidative stress
- insulin resistance
- mouse model
- endoplasmic reticulum stress
- cell death
- pi k akt
- signaling pathway
- poor prognosis
- toll like receptor
- binding protein
- cerebral ischemia
- cognitive decline
- type diabetes
- ms ms
- inflammatory response
- high resolution
- smoking cessation
- mild cognitive impairment
- tyrosine kinase
- atomic force microscopy
- blood brain barrier
- single molecule
- protein kinase