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Bacteriophage-based approach for treatment of urinary tract infections: a quick outlook.

Bartłomiej GrygorcewiczMarta RoszakJoanna JabłońskaAdrian AugustyniakPatrycja OlszewskaBartosz WojciukDominika MiłekNatalia SerwinArtur CzajkowskiElżbieta Cecerska-HeryćRafał RakoczyAneta Cymbaluk-Płoska
Published in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (2023)
Urinary tract infections (UTIs) are among the most common bacterial infections affecting millions worldwide. The increasing emergence of antibiotic-resistant bacteria has become a serious concern in managing UTIs. Therefore, there is a growing interest in using bacteriophages as an alternative or adjunct therapy for UTIs. Bacteriophages are viruses that infect and kill bacteria, making them a promising tool for treating UTIs caused by antibiotic-resistant bacteria. This article provides a quick outlook on using bacteriophages to treat UTIs. We summarize the current understanding of the biology of bacteriophages, the challenges associated with developing phage-based therapies, and the promising results of several case reports and clinical trials. We also highlight the potential of phage therapy as a valuable tool in the fight against antibiotic-resistant UTIs. This quick outlook on a bacteriophage-based approach for treating UTIs offers a timely and informative summary of the current research in this field.
Keyphrases
  • urinary tract infection
  • clinical trial
  • pseudomonas aeruginosa
  • randomized controlled trial
  • stem cells
  • mesenchymal stem cells
  • open label
  • phase iii