Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation.
Linna B O RodriguesFlávia A LimaCamila P B AlvesElisângela Martins-SantosMarta M G AguiarCleida A OliveiraRodrigo L OréficeLucas A M FerreiraGisele Assis Castro GoulartPublished in: Pharmaceutical research (2020)
The studies demonstrated that the encapsulation of AD in SLNs through the formation of an ion pair is a valuable alternative to diminish the adverse skin reactions caused by AD and can optimize patient adherence to treatment.