Antibacterial effect and mechanisms of action of forsythoside B, alone and in combination with antibiotics, against Acinetobacter baumannii and Pseudomonas aeruginosa.

FB expands the antibacterial spectrum and enhances the effectiveness of existing antibiotics against resistant bacterial strains, making it a promising adjuvant for treating gram-negative bacterial infections. This study highlights the potential of FB in combating antibiotic resistance and suggests further research into its mechanisms and drug development applications. It provides a framework for studying the interaction between natural products and microorganisms, revealing new biological mechanisms.