Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/β-catenin signaling.

Yonglin XieWei HeLi MaReng RenShuxu YangQin Lu

Published in: CNS neuroscience & therapeutics (2023)

This study demonstrated that TREM-1 deteriorated BBB permeability via modulating the expression of interendothelial junction molecules after ICH, and this regulation is partly mediated by the SYK/β-catenin signaling pathway.

Keyphrases

tyrosine kinase
endothelial cells
poor prognosis
blood brain barrier
brain injury
binding protein
type diabetes
insulin resistance
skeletal muscle
adipose tissue