Inhibitory Traits of Dendrosome Curcumin (DNC) on Breast Cancer Compared to Curcumin Single Compound.
Yasemin Khudiar AlghanimiAbdolmajid GhasemianPublished in: Journal of gastrointestinal cancer (2021)
The rate of apoptosis (programmed cell death) was enhanced, but necrosis was decreased in treated cancer cells compared to those treated with single curcumin. Accordingly, the DNC can be applied to hinder the growth and dissemination of cancer cells as a preferred approach to reduce the complications of other strategies such as chemotherapy and radiation therapy. Indeed, we concluded that DNC enhanced the expression of MEG3, a tumor suppressor, at 25 μm dose, but reduced the expression of the FOXCUT gene, possibly via the methylation of the gene. Thereby, DNC exerted a promising tumor inhibitory growth potential for the eradication of cancer cells.
Keyphrases
- genome wide
- poor prognosis
- radiation therapy
- copy number
- locally advanced
- oxidative stress
- dna methylation
- newly diagnosed
- cell death
- squamous cell carcinoma
- cell cycle arrest
- cell proliferation
- helicobacter pylori
- endoplasmic reticulum stress
- genome wide identification
- transcription factor
- young adults
- genome wide analysis
- signaling pathway