Parkinson's disease: evolution of cognitive impairment and CSF Aβ1-42 profiles in a prospective longitudinal study.

Stefanie LercheIsabel WursterBenjamin RöbenGerrit MachetanzMilan ZimmermannFelix BernhardElke StranskyChristian DeuschleClaudia SchulteOskar HanssonHenrik ZetterbergThomas GasserDaniela BergWalter MaetzlerKathrin Brockmann

Published in: Journal of neurology, neurosurgery, and psychiatry (2018)

We conclude that in patients with sporadic PD, low levels of Aβ1-42 are associated with a higher risk of developing cognitive impairment earlier in the disease process at least in a subgroup of patients.

Keyphrases

cognitive impairment
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
randomized controlled trial
early onset
patient reported
study protocol
phase iii
open label