PSORS1 Locus Genotyping Profile in Psoriasis: A Pilot Case-Control Study.
Noha Z TawfikHoda Y AbdallahRanya HassanAlaa HosnyDina E GhanemAya AdelMona A AtwaPublished in: Diagnostics (Basel, Switzerland) (2022)
(1) Background: The psoriasis susceptibility 1 (PSORS1) locus, located within the major histocompatibility complex, is one of the main genetic determinants for psoriasis, the genotyping profile for three single-nucleotide polymorphisms (SNPs) comprising the PSORS1 locus: rs1062470 within PSORS1C1/CDSN genes, rs887466 within PSORS1C3 gene, rs10484554 within LOC105375015 gene, were investigated and correlated with psoriasis risk and severity. (2) Methods: This pilot case-controlled study involved 100 psoriatic patients and 100 healthy individuals. We investigated three SNPs and assessed the relative gene expression profile for the PSORS1C1 gene. We then correlated the results with both disease risk and severity. (3) Results: The most significantly associated SNP in PSORS1 locus with psoriasis was rs10484554 with its C/T genotype 5.63 times more likely to develop psoriasis under codominant comparison. Furthermore, C/T and T/T genotypes were 5 times more likely to develop psoriasis. The T allele was 3 times more likely to develop psoriasis under allelic comparison. The relative gene expression of PSORS1C1 for psoriatic patients showed to be under-expressed compared to normal controls. (4) Conclusions: Our study revealed the association of the three studied SNPs with psoriasis risk and severity in an Egyptian cohort, indicating that rs10484554 could be the major key player in the PSORS1 locus.
Keyphrases
- genome wide
- dna methylation
- gene expression
- end stage renal disease
- copy number
- atopic dermatitis
- newly diagnosed
- rheumatoid arthritis
- ejection fraction
- genome wide identification
- prognostic factors
- chronic kidney disease
- peritoneal dialysis
- high throughput
- randomized controlled trial
- genome wide association study
- disease activity
- single cell
- transcription factor
- mass spectrometry
- ankylosing spondylitis
- genetic diversity
- patient reported outcomes