Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure.
Wenyuan LiWei LiXun LiLuwen WangYao WangPublished in: Apoptosis : an international journal on programmed cell death (2023)
This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The inhibition of SLC7A11 transcription was weakened after blocking of P53 binding to the promoter region of the SLC7A11 gene. The SLC7A11-GSH-GPX4 antiferroptotic pathway was subsequently activated, and the level of ferroptosis in ALF hepatocytes was inhibited.
Keyphrases
- liver failure
- cell death
- hepatitis b virus
- liver injury
- transcription factor
- poor prognosis
- dna methylation
- gene expression
- drug induced
- genome wide
- atomic force microscopy
- copy number
- single molecule
- long non coding rna
- acute respiratory distress syndrome
- high resolution
- extracorporeal membrane oxygenation
- binding protein
- respiratory failure
- aortic dissection