Autologous hematopoietic stem cell transplantation following alemtuzumab therapy in aggressive multiple sclerosis: A report of three cases.
Giacomo BoffaElvira SbragiaAnna Maria RaiolaRiccardo VaraldoElisabetta CapelloPaolo GalloFranco GranellaGianluigi MancardiMatilde InglesePublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
The management of multiple sclerosis patients with persistent disease activity under alemtuzumab treatment is not established yet. Concerns have been raised on the safety of autologous haematopoietic stem cell transplantation (aHSCT) after alemtuzumab treatment because of the risk of serious infectious adverse events. We report short-term safety and efficacy data from three patients treated with aHSCT following alemtuzumab treatment. Early adverse events were consistent with expected transplant toxicities. All patients were free of disease activity at the last follow-up. Our data suggest that aHSCT can be considered as a rescue treatment strategy for MS patients with persistent disease activity during alemtuzumab treatment.
Keyphrases
- disease activity
- multiple sclerosis
- rheumatoid arthritis
- systemic lupus erythematosus
- stem cell transplantation
- rheumatoid arthritis patients
- ankylosing spondylitis
- end stage renal disease
- juvenile idiopathic arthritis
- stem cells
- chronic kidney disease
- machine learning
- combination therapy
- ms ms
- white matter
- ejection fraction
- big data
- deep learning
- peritoneal dialysis
- mesenchymal stem cells
- prognostic factors