New synthetic derivatives of isoindoline-dione: synthesis, neuroprotection assay and impact on the expression level of oxidative stress-related genes in neuronal-like cell line.
Abdolrahim PourpariziMina VaziriniaFatemeh PourrajabHamid NadriAsghar DavoodPublished in: Journal of receptor and signal transduction research (2024)
Isoindoline derivatives demonstrated a neuroprotective effect on SH-SY5Y cells through various neuroprotective mechanisms, although more studies are needed.
Keyphrases
- cerebral ischemia
- induced apoptosis
- oxidative stress
- subarachnoid hemorrhage
- brain injury
- blood brain barrier
- poor prognosis
- cell cycle arrest
- endoplasmic reticulum stress
- structure activity relationship
- signaling pathway
- dna damage
- high throughput
- ischemia reperfusion injury
- case control
- binding protein
- cell death
- cell proliferation
- pi k akt
- heat stress