PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression.
Hong-Yong CuiWei WeiMei-Rui QianRuo-Fei TianXin FuHong-Wei LiGang NanTing YangPeng LinXi ChenYu-Meng ZhuBin WangXiu-Xuan SunJian-Hua DouJian-Li JiangLing LiShi-Jie WangZhi-Nan ChenPublished in: Cancer communications (London, England) (2022)
PDAP1 facilitates mucosal restitution and carcinogenesis in colitis-associated cancer. c-Myc-driven upregulation of PDAP1 promotes proliferation, migration, invasion, and metastasis of CRC cells via the EGFR-MAPK-FRA-1 signaling axis. These findings indicated that PDAP1 inhibition is warranted for CRC patients with PDAP1 overexpression.
Keyphrases
- signaling pathway
- induced apoptosis
- cell proliferation
- small cell lung cancer
- cell cycle arrest
- papillary thyroid
- pi k akt
- ulcerative colitis
- epidermal growth factor receptor
- poor prognosis
- tyrosine kinase
- squamous cell
- transcription factor
- squamous cell carcinoma
- lymph node metastasis
- long non coding rna
- childhood cancer