Porous Se@SiO 2 nanoparticles improve oxidative injury to promote muscle regeneration via modulating mitochondria.
Yu-Xia YangMing-Sheng LiuXi-Jian LiuYu-Cheng ZhangYang-Yang HuRang-Shan GaoEr-Kai PangLei HouJing-Cheng WangWen-Yong FeiPublished in: Nanomedicine (London, England) (2022)
Background: Acute skeletal muscle injuries are common among physical or sports traumas. The excessive oxidative stress at the site of injury impairs muscle regeneration. The authors have recently developed porous Se@SiO 2 nanoparticles (NPs) with antioxidant properties. Methods: The protective effects were evaluated by cell proliferation, myogenic differentiation and mitochondrial activity. Then, the therapeutic effect was investigated in a cardiotoxin-induced muscle injury rat model. Results: Porous Se@SiO 2 NPs significantly protected the morphological and functional stability of mitochondria, thus protecting satellite cells from H 2 O 2 -induced damage to cell proliferation and myogenic differentiation. In the rat model, intervention with porous Se@SiO 2 NPs promoted muscle regeneration. Conclusion: This study reveals the application potential of porous Se@SiO 2 NPs in skeletal muscle diseases related to mitochondrial dysfunction.
Keyphrases
- skeletal muscle
- oxidative stress
- diabetic rats
- cell proliferation
- stem cells
- insulin resistance
- metal organic framework
- drug induced
- magnetic nanoparticles
- high glucose
- tissue engineering
- highly efficient
- randomized controlled trial
- dna damage
- cell death
- mental health
- cell cycle
- induced apoptosis
- signaling pathway
- liver failure
- body mass index
- pi k akt
- respiratory failure
- endoplasmic reticulum
- high resolution
- heat shock
- acute respiratory distress syndrome