Thanksgiving to Yeast, the HMGB Proteins History from Yeast to Cancer.
Mónica Lamas-MaceirasÁngel Vizoso-VázquezAida Barreiro-AlonsoMaría Cámara-QuílezMaría Esperanza CerdánPublished in: Microorganisms (2023)
Yeasts have been a part of human life since ancient times in the fermentation of many natural products used for food. In addition, in the 20th century, they became powerful tools to elucidate the functions of eukaryotic cells as soon as the techniques of molecular biology developed. Our molecular understandings of metabolism, cellular transport, DNA repair, gene expression and regulation, and the cell division cycle have all been obtained through biochemistry and genetic analysis using different yeasts. In this review, we summarize the role that yeasts have had in biological discoveries, the use of yeasts as biological tools, as well as past and on-going research projects on HMGB proteins along the way from yeast to cancer.
Keyphrases
- saccharomyces cerevisiae
- dna repair
- gene expression
- papillary thyroid
- squamous cell
- endothelial cells
- dna damage
- induced apoptosis
- squamous cell carcinoma
- single molecule
- dna methylation
- dna damage response
- quality improvement
- childhood cancer
- single cell
- cell death
- bone marrow
- stem cells
- lymph node metastasis
- young adults
- copy number
- oxidative stress
- pluripotent stem cells
- mesenchymal stem cells
- risk assessment
- signaling pathway
- pi k akt