Different Nanotechnology Approaches for Ciprofloxacin Delivery Against Multidrug-Resistant Microbes.
Ashagrachew Tewabe YayehradGebremariam Birhanu WondieTesfa MarewPublished in: Infection and drug resistance (2022)
The percentages of organisms exhibiting antimicrobial resistance, especially resistance to multiple antibiotics, are incessantly increasing. Studies investigated that many bacteria are being resistant to ciprofloxacin. This review addresses the current knowledge on nano-based ciprofloxacin delivery approaches to improve its effectiveness and overcome the resistance issues. Ciprofloxacin delivery can be modified by encapsulating with or incorporating in different polymeric nanoparticles such as chitosan, PLGA, albumin, arginine, and other organic and inorganic nanostructure systems. Most of these nano-approaches are promising as an alternative strategy to improve the therapeutic effectiveness of ciprofloxacin in the future.
Keyphrases
- pseudomonas aeruginosa
- antimicrobial resistance
- drug delivery
- multidrug resistant
- randomized controlled trial
- systematic review
- cystic fibrosis
- healthcare
- acinetobacter baumannii
- gram negative
- drug release
- cancer therapy
- high resolution
- drug resistant
- current status
- atomic force microscopy
- mass spectrometry
- single molecule
- walled carbon nanotubes