Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts.

Anuja Sathe Kaishu Mason Susan M Grimes Zilu Zhou Billy T Lau Xiangqi Bai Andrew Su Xiao Tan HoJoon Lee Carlos J Suarez Quan H Nguyen George Poultsides Nancy R Zhang Hanlee P Ji

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

We demonstrated that mCRC in the liver is characterized by transcriptional alterations of macrophages in the TME. Intercellular networking between macrophages and fibroblasts supports CRC growth in the immunosuppressed metastatic niche in the liver. These features can be used to target immune checkpoint resistant MSS tumors.

Keyphrases

squamous cell carcinoma
small cell lung cancer
gene expression
transcription factor
oxidative stress
heat shock