AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea.

Amira D MahmoudSophronia LewisLara JuričićUtibe-Abasi UdohSandy HartmannMaurits A JansenOluseye A OgunbayoPaolo PuggioniAndrew P HolmesPrem KumarJorge Navarro-DoradoMarc ForetzBenoit ViolletMayank B DutiaIan MarshallA Mark Evans

Published in: American journal of respiratory and critical care medicine (2017)

AMPK is required to coordinate the activation by hypoxia of brainstem respiratory networks, and deficiencies in AMPK expression precipitate hypoventilation and apnea, even when carotid body afferent input is normal.

Keyphrases

protein kinase
positive airway pressure
obstructive sleep apnea
sleep apnea
poor prognosis
endothelial cells
binding protein
replacement therapy
long non coding rna
respiratory tract
skeletal muscle