Extracellular matrix remodeling effects of serum amyloid A1 in the human amnion: Implications for fetal membrane rupture.
Ya-Wei WangWang-Sheng WangLu-Yao WangYi-Rong BaoJiang-Wen LuYi LuChu-Yue ZhangWen-Jiao LiKang SunHao YingPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
These data highlight a possible role for SAA1 in ECM remodeling preceding membrane rupture by regulating the expression of collagenases MMP-1, MMP-8, MMP-13, and LOXL1 through TLR4-mediated activation of the NF-κB and MAPK pathways in amnion fibroblasts.
Keyphrases
- extracellular matrix
- signaling pathway
- cell migration
- endothelial cells
- oxidative stress
- poor prognosis
- pi k akt
- toll like receptor
- inflammatory response
- nuclear factor
- immune response
- lps induced
- electronic health record
- induced pluripotent stem cells
- big data
- long non coding rna
- machine learning
- deep learning
- data analysis