Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells.
Ana Gabriela Ramos-MartinezMonica Alejandra Valtierra-AlvaradoMariana Haydee Garcia-HernandezRogelio Hernandez-PandoJulio Enrique Castañeda-DelgadoCéline CougouleBruno Rivas-SantiagoOlivier NeyrollesJose Antonio Enciso-MorenoGeanncarlo Lugo-VillarinoCarmen Judith SerranoPublished in: Memorias do Instituto Oswaldo Cruz (2019)
Our findings suggest that variability in virulence among Mtb clinical strains affects the capacity of DCs to respond to pathogenic challenge and mount an immune response against it, highlighting important parallels to studies previously done in mouse models.
Keyphrases
- mycobacterium tuberculosis
- dendritic cells
- escherichia coli
- immune response
- pseudomonas aeruginosa
- staphylococcus aureus
- antimicrobial resistance
- biofilm formation
- pulmonary tuberculosis
- endothelial cells
- mouse model
- regulatory t cells
- induced pluripotent stem cells
- toll like receptor
- pluripotent stem cells
- case control
- cystic fibrosis