Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect.

Unnur StyrkársdóttirLilja StefansdottirGudmar ThorleifssonOlafur A StefanssonSaedis SaevarsdottirSigrun H LundThorunn RafnarKazuyuki HoshijimaKendra NovakNatividad OreiroIgnacio Rego PerezChanning HansenNikolas KazmersLambertus A KiemeneyFrancisco Javier BlancoTyler BarkerMargreet Kloppenburg Michael J JurynecDaniel F GudbjartssonHelgi JonssonUnnur ThorsteinsdottirKari Stefansson

Published in: Annals of the rheumatic diseases (2023)

We report on significant genetic associations with EHOA. The results support the view of EHOA as a form of severe hand OA and partly separate it from OA in larger joints.

Keyphrases

knee osteoarthritis
systematic review
genome wide
copy number
meta analyses
rheumatoid arthritis
early onset
dna methylation
randomized controlled trial
gene expression
case control