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Integrative functional genomics identifies SLE causal genetic variant in the IRF5 risk locus.

Guojun HouTian ZhouNing XuZhihua YinXinyi ZhuYutong ZhangYange CuiJianyang MaYuanjia TangZhaorui ChengYiwei ShenYashuo ChenLing-Hua ZouYong-Fei WangZihang YinYa GuoHuihua DingZhizhong YeNan Shen
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
These results demonstrate that rs4728142-A allele increases the SLE risk by affecting ZBTB3 binding, chromatin status, and regulating IRF5 expression, establishing a biological link between genetic variation and lupus pathogenesis.
Keyphrases
  • systemic lupus erythematosus
  • disease activity
  • genome wide
  • poor prognosis
  • dendritic cells
  • dna damage
  • rheumatoid arthritis
  • transcription factor
  • dna methylation
  • long non coding rna
  • oxidative stress
  • dna binding