A small molecule improves diabetes in mice expressing human islet amyloid polypeptide.
Vriti BhagatC Bruce VercherePublished in: Islets (2023)
In recent years, the number of studies on islet and beta cell autophagy have substantially increased due to growing interest in the role of autophagy in maintaining cellular homeostasis in diabetes. In type 2 diabetes, human islet amyloid polypeptide (hIAPP) aggregates to form higher structure oligomers and fibrils that are toxic to beta cells and induce islet inflammation. The primary mechanism of oligomer and fibril clearance in beta cells is through the autophagic pathway, a process that is impaired in type 2 diabetes. Thus, toxic oligomeric and fibrillar forms of hIAPP accumulate in type 2 diabetic islets. Recently, Kim et al . characterized the ability of a small molecule autophagy enhancer, MSL-7, to clear hIAPP oligomers in mice expressing hIAPP. Herein, we outline the primary findings of the study, limitations, and future directions to further investigate the therapeutic potential of autophagy enhancers to treat diabetes.
Keyphrases
- type diabetes
- cell death
- small molecule
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest
- glycemic control
- oxidative stress
- signaling pathway
- cardiovascular disease
- endothelial cells
- insulin resistance
- induced pluripotent stem cells
- protein protein
- stem cells
- high fat diet induced
- pluripotent stem cells
- cell therapy
- single cell
- wild type
- cell proliferation
- transcription factor
- metabolic syndrome
- pi k akt