High FGFR1-4 mRNA Expression Levels Correlate with Response to Selective FGFR Inhibitors in Breast Cancer.

Mònica Sánchez-GuixéCinta HierroJosé JiménezCristina ViaplanaGuillermo VillacampaErika MonelliFara Brasó-MaristanyZighereda OgbahMireia ParésMarta GuzmánJudit GruesoOlga RodríguezMafalda OliveiraAnalía AzaroElena Garralda Josep Tabernero Oriol Casanovas Maurizio Scaltriti Aleix PratRodrigo DienstmannPaolo G Nuciforo Cristina SauraMariona GrauperaAna VivancosJordi RodonVioleta Serra

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Tailored therapy with FGFRis in molecularly selected MBC based on high FGFR1-4 mRNA levels warrants prospective validation in patients with CDK4/6i-resistant luminal breast cancer and in patients with TNBC without targeted therapeutic options.

Keyphrases

cell cycle
cell proliferation
young adults
binding protein
breast cancer risk