The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study.

Fatma M GhoneimHani AlrefaiAyman Z ElsamanoudySalwa M Abo El-KhairHanaa A Khalaf

Published in: Biology (2020)

ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

Keyphrases

oxidative stress
diabetic rats
induced apoptosis
poor prognosis
cell death
high fat diet
metabolic syndrome
ischemia reperfusion injury
type diabetes
drug induced
adipose tissue
long non coding rna
insulin resistance
newly diagnosed