Association of M2 Macrophages, Th2, and B Cells With Pathomechanism in Microscopic Polyangiitis Complicated by Interstitial Lung Disease.
Shogo MatsudaTakuya KotaniHiroko KuwabaraTakayasu SuzukaTakao KiboshiYumiko WadaTakaaki IshidaYouhei FujikiHideyuki ShibaKenichiro HataTakeshi ShodaYoshinobu HiroseTohru TakeuchiPublished in: The Journal of rheumatology (2022)
The activation of M2 macrophages, Th2 cells, and B cells plays a key role in the pathomechanism of MPA-ILD. Classification of MPA-ILD based on serum biomarker profile would be useful in predicting the disease activity and the complications of severe infection in MPA-ILD.
Keyphrases
- interstitial lung disease
- rheumatoid arthritis
- disease activity
- systemic sclerosis
- rheumatoid arthritis patients
- systemic lupus erythematosus
- ankylosing spondylitis
- induced apoptosis
- idiopathic pulmonary fibrosis
- juvenile idiopathic arthritis
- machine learning
- cell cycle arrest
- deep learning
- early onset
- risk factors
- endoplasmic reticulum stress
- cell death
- pi k akt