Identification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer's disease.

Yejoo ChoiSungho ShinHyo Jin SonNa-Hee LeeSu Hyeon MyeongCheolju LeeHyemin JangSoo Jin ChoiHee Jin KimDuk L Na

Published in: Stem cell research & therapy (2023)

This study identified two proteins (RCN3 and FSTL3) that may be potential biomarkers for predicting MSC response and four proteins (SCRG1, NPDC1, ApoE, CysC) that may be potential biomarkers for monitoring MSC response in patients with AD. Further studies are needed to validate our results. Trial registration Clinical Trials.gov, NCT02054208. Registered on 4 February 2014. Samsung Medical Center IRB File No.2017-04-025. Registered on 20 June 2017.

Keyphrases

clinical trial
mesenchymal stem cells
type diabetes
study protocol
phase ii
phase iii
randomized controlled trial
stem cells
high fat diet
metabolic syndrome
adipose tissue
cell therapy
mild cognitive impairment
bioinformatics analysis