The association between increasing oral anticoagulant prescribing and atrial fibrillation related stroke in Ireland.
Cormac KennedyAhmed GabrJoan McCormackRónán CollinsMichael BarryJoe HarbisonPublished in: British journal of clinical pharmacology (2021)
Large increases in OAC utilisation have not resulted in changes in ischaemic stroke rates at a national level. The percentage of ischaemic strokes with a previous diagnosis of AF has decreased indicating a possible benefit from greater OAC utilisation. However, the percentage presenting with an ischaemic stroke while on OAC treatment is increasing. The increase in patients presenting with stroke while treated with OAC may largely reflect the national increase in patients prescribed DOACs but the findings raise concerns about treatment failures. The real-world effectiveness of DOACs requires further examination.
Keyphrases
- atrial fibrillation
- direct oral anticoagulants
- oral anticoagulants
- catheter ablation
- randomized controlled trial
- left atrial
- newly diagnosed
- primary care
- heart failure
- end stage renal disease
- ejection fraction
- left atrial appendage
- venous thromboembolism
- quality improvement
- percutaneous coronary intervention
- emergency department
- peritoneal dialysis
- combination therapy
- subarachnoid hemorrhage
- case report
- patient reported outcomes
- cerebral ischemia
- smoking cessation
- drug induced