Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells.
Mohamed Yousif IbrahimNajihah Mohd HashimFatima Abdelmutaal Ahmed OmerMuhammad Salisu AbubakarHoyam Adam MohammedSuzy Munir SalamaSoher Nagi JayashPublished in: International journal of molecular sciences (2023)
In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.
Keyphrases
- induced apoptosis
- oxidative stress
- cell cycle arrest
- endoplasmic reticulum stress
- cell death
- squamous cell carcinoma
- stem cells
- diabetic rats
- randomized controlled trial
- single cell
- dna damage
- clinical trial
- mesenchymal stem cells
- anti inflammatory
- endothelial cells
- cell therapy
- bone marrow
- climate change
- polycyclic aromatic hydrocarbons
- heat stress