A multi-institutional pilot clinical trial of spectroscopic MRI-guided radiation dose escalation for newly diagnosed glioblastoma.

Karthik RameshEric A MellonSaumya S GurbaniBrent D WeinbergEduard SchreibmannSulaiman A SheriffMohammed GoryawalaMacarena de le FuenteBree R EatonJim ZhongAlfredo D VoloschinSoma SenguptaErin M DunbarMatthias HoldhoffPeter B BarkerAndrew A MaudsleyLawrence R KleinbergHyunsuk ShimHui-Kuo G Shu

Published in: Neuro-oncology advances (2022)

Dose-escalated RT to 75 Gy guided by sMRI appears feasible and safe for patients with newly diagnosed GBMs. OS outcome is promising and warrants additional testing. Based on these results, a randomized phase II trial is in development.

Keyphrases

newly diagnosed
open label
clinical trial
study protocol
magnetic resonance imaging
molecular docking
phase ii
contrast enhanced
phase iii
randomized controlled trial
computed tomography
diffusion weighted imaging