FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress.
Qhaweni DhlaminiWei WangGuifeng FengAiping ChenLei ChongXue LiQuan LiJin WuDepu ZhouJie WangHailin ZhangJin-San ZhangPublished in: Molecular medicine (Cambridge, Mass.) (2022)
Altogether, our results suggest that FGF1 pretreatment is protective against LPS-induced ALI through mediating anti-inflammatory and antioxidant effects, which may be attributed to the downregulation of TLR4 expression and inhibition of NF-κB activation, as well as promotion of antioxidant defenses. Therefore, FGF1 administration may prove beneficial in preventative strategies for ALI/ARDS.
Keyphrases
- lps induced
- oxidative stress
- inflammatory response
- anti inflammatory
- lipopolysaccharide induced
- toll like receptor
- diabetic rats
- ischemia reperfusion injury
- dna damage
- poor prognosis
- induced apoptosis
- acute respiratory distress syndrome
- cell proliferation
- extracorporeal membrane oxygenation
- signaling pathway
- immune response
- mouse model
- binding protein
- mechanical ventilation
- nuclear factor
- heat shock