Gut bacterial metabolites modulate endoplasmic reticulum stress.
Xiaobo KeKwontae YouMatthieu PichaudHenry J HaiserDaniel B GrahamHera VlamakisJeffrey A PorterRamnik J XavierPublished in: Genome biology (2021)
Our study identified novel links between classes of gut microbe-derived metabolites and the ER stress response, suggesting the potential for these metabolites to contribute to gut ER homeostasis and providing insight into the molecular mechanisms by which gut microbes impact intestinal epithelial cell homeostasis.