Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway.

Meiyue LouMasaaki IwatsukiXiyu WuWeiliyun ZhangChihiro MatsumotoHideo Baba

Published in: Annals of surgical oncology (2023)

Targeting CAF-derived IL-8 may defeat PD-L1 upregulation-mediated immune resistance in GC cells, which provides a novel approach to improve the immunotherapeutic efficacies of patients with GC.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
oxidative stress
pi k akt
cell proliferation
gas chromatography
poor prognosis
lps induced
cancer therapy
endoplasmic reticulum stress
nuclear factor
drug delivery
mass spectrometry
inflammatory response
toll like receptor